![]() 2Ī tree nut is a fruit consisting of a hard nutshell protecting the kernel. Tree nut allergy is observed worldwide and is frequent in up to 0.05% to 4.9% of individuals, as reported in a systematic review. 1 An allergic reaction to nuts can cause severe and occasionally lethal results. Tree nuts are common food allergen sources that induce IgE-mediated allergic reactions. Nuts have become part of a modern healthy diet, and this enhanced consumption is reflected in an increased prevalence of nut allergies. Patients can eat nuts that they know are safe at home, but should avoid them when eating out because of the risk of cross-contamination. However, this is difficult to achieve and can result in a severely restricted diet. Complete avoidance of nuts is the safest approach for nut-allergic subjects. ![]() The resolution of tree nut allergies has been reported however, only a few studies are available in this regard. IgE testing of the storage proteins Cor a 14, Cor a 9, Jug r 1, and Ana o 3 increases diagnostic specificity in assessing hazelnut, walnut, and cashew allergies in children, respectively. Systematic literature reviews and meta-analyses on the diagnostic accuracy of specific immunoglobulin E (sIgE) for commercially available nut components have recently been published. Bet v 1 homologs and profilins are involved in pollen-related tree nut allergies. ![]() Most proteins implicated in tree nut allergic reactions are members of the lipid transfer protein, 2S albumin, vicilin, legumin, and oleosin protein families. Over the last 2 decades, the rates of allergic reactions and anaphylaxis have increased in different countries. Allergies to tree nuts are observed worldwide and are found in up to 4.9% of people in unspecific populations. Allergic reactions to nuts can lead to severe and occasionally lethal reactions. Health authorities endorse the intake of tree nuts because they are regarded as nutritious. Tree nuts are a powerful and common source of food allergens that induce IgE-mediated allergic reactions. ![]()
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